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METROGEL-VAGINAL affords negligible peak serum amounts and systemic publicity (AUCs) of metronidazole as compared to five hundred mg oral metronidazole dosing. Though these decrease amounts of exposure are more unlikely to provide the typical reactions seen with oral metronidazole, the possibility of these and also other reactions can not be excluded presently.

Metronidazole is a nitroimidazole and should be employed with care in people with evidence of, or historical past of blood dyscrasia.

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Metronidazole has demonstrated proof of carcinogenic action in a number of scientific studies involving Continual, oral administration in mice and rats although not in scientific studies involving hamsters.

Oral metronidazole continues to be documented to potentiate jnetoto the anticoagulant effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time.